the science behind our formulas


The science behind future nutrients


 

L- Theanine

L-theanine significantly increases activity in the alpha frequency band which indicates that it relaxes the mind without inducing drowsiness.

Study Link: L-theanine, a natural constituent in tea, and its effect on mental state

L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent

Study Link: The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.

L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects prone to have high anxiety.

Study Link: Effects of l-theanine on attention and reaction time response[/vc_column_text]

L-Theanine & Caffeine

Studies show that caffeine and L-theanine can have synergistic effects. The combination of the two is particularly potent at improving brain function

L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance

https://www.ncbi.nlm.nih.gov/pubmed/18641209

Combining L-theanine with caffeine, at levels and ratios equivalent to one to two cups of tea, eliminated the vasoconstrictive effect and behavioural effects of caffeine.

https://www.ncbi.nlm.nih.gov/pubmed/25761837

Guarana Extract (Paullinia cupana)

Guaraná improved secondary memory performance and increased alert and content mood ratings

https://www.ncbi.nlm.nih.gov/pubmed/16533867

Data confirms the acute benefits of multivitamins with guaraná on mood and cognitive performance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798923/

https://www.ncbi.nlm.nih.gov/pubmed/24067387

Guarana is an effective, inexpensive, and nontoxic alternative for the short-term treatment of fatigue in BC patients receiving systemic chemotherapy.

https://www.ncbi.nlm.nih.gov/pubmed/21612429

A dose of 0.3 mg/ml showed a significant increase in physical capacity when subjected to a stressful situation such as forced swimming after 100 and 200 days of treatment.

https://www.ncbi.nlm.nih.gov/pubmed/9080343

Green Tea Extract (Camellia sinensis) 98% POLYPHENOLS 50% EGCG

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

https://www.ncbi.nlm.nih.gov/pubmed/23507223

Dietary supplementation with green tea extract promotes enhanced human leukocyte activity

https://www.ncbi.nlm.nih.gov/pubmed/26259232

Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions

https://www.ncbi.nlm.nih.gov/pubmed/12587987

Acute neurocognitive effects of epigallocatechin gallate (EGCG)

https://www.ncbi.nlm.nih.gov/pubmed/22127270     

Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG)

https://www.ncbi.nlm.nih.gov/pubmed/16859659

Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis

https://www.ncbi.nlm.nih.gov/pubmed/22692966

Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue

https://examine.com/supplements/green-tea-catechins/#ref46

Antioxidant capacities of flavones and benefits in oxidative-stress related diseases

https://www.ncbi.nlm.nih.gov/pubmed/25547095

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome

https://www.ncbi.nlm.nih.gov/pubmed/23507223

Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation

https://www.ncbi.nlm.nih.gov/pubmed/22389082

Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis

https://www.ncbi.nlm.nih.gov/pubmed/22692966

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome

https://www.ncbi.nlm.nih.gov/pubmed/20088847

Beneficial effects of green tea: A literature review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855614/

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Rhodiola Extract (Rhodiola rosea) (3% Rosavins 1% Salidrosides)

These results suggest that RRE can reduce general fatigue under certain stressful conditions.

https://www.ncbi.nlm.nih.gov/pubmed/11081987

All tests showed clinically relevant improvements with regard to stress symptoms, disability, functional impairment and overall therapeutic effect.

https://www.ncbi.nlm.nih.gov/pubmed/22228617

Acute Rhodiola rosea intake can improve endurance exercise capacity in young healthy volunteers.

https://www.ncbi.nlm.nih.gov/pubmed/15256690

Reduces stress related fatigue and improvement in physical fitness, mental fatigue and neuro-motor function.

https://www.ncbi.nlm.nih.gov/pubmed/10839209

Anti-fatigue effect

https://www.ncbi.nlm.nih.gov/pubmed/12725561

Capacity for mental work significantly increased relative to placebo.

https://examine.com/rubric/effects/view/1b297ffd9568a57a5640be12dd5a107e/c963830f5450a76157ee05918b840cb4/all/

Rhodiola Rosea may increase the adaptogen ability to physical exercise.

https://www.ncbi.nlm.nih.gov/pubmed/20308973

It is concluded that the standardized extract SHR-5 shows anti-depressive potency in patients with mild to moderate depression when administered in dosages of either 340 or 680 mg/day over a 6-week period.

https://www.ncbi.nlm.nih.gov/pubmed/17990195

Rhodiola rosea L. roots have potent antidepressant activity by inhibiting MAO A and may also find application in the control of senile dementia by their inhibition of MAO B.

https://www.ncbi.nlm.nih.gov/pubmed/19168123/

 

SUMMARY:

https://www.healthline.com/nutrition/rhodiola-rosea#section8

Panax Ginseng (Root)

improve cognitive performance during sustained mental activity – Overall these data suggest that Panax ginseng can improve performance and subjective feelings of mental fatigue during sustained mental activity.

https://www.ncbi.nlm.nih.gov/pubmed/15982990

Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults.

https://www.ncbi.nlm.nih.gov/pubmed/20737519

https://www.ncbi.nlm.nih.gov/pubmed/16401645

The results of this study suggest that RG supplementation could reduce exercise-induced muscle damage and inflammatory responses, resulting in improvements in insulin sensitivity.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X11008944

PANAX NOTOGINSENG SUPPLEMENTATION ENHANCES PHYSICAL PERFORMANCE DURING ENDURANCE EXERCISE

https://insights.ovid.com/crossref?an=00124278-200502000-00019

Siberian Ginseng Extract (Eleutherococcus Senticosus)

Active components in Eleutherococcus senticosus contained in Taiga Wurzel preparation affect cellular defence and physical fitness, as well as lipid metabolism.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/%28SICI%291099-1573%28200002%2914%3A1%3C30%3A%3AAID-PTR543%3E3.0.CO%3B2-V

Significantly increases physical working capacity in men

https://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-969114

(For Elderly People)

Senticosus safely improves some aspects of mental health and social functioning after 4 weeks of therapy,

https://www.ncbi.nlm.nih.gov/pubmed/15207399

Organic Gotu Kola Concentrate (Centella asiatica)

Effective in improving cognitive impairment after stroke infarction but is not more beneficial than a therapy of folic acid 3 mg/day. Among the seven cognitive domains assessed by the MoCA-Ina test, gotu kola treatment showed better improvement in delayed memory recall compared with folic acid treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908235/

CAW improves cognitive performance and affects mitochondrial and antioxidant response pathways in vivo on mice.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764102/

The results showed that the high dose of the plant extract enhanced working memory and increased N100 component amplitude of event-related potential. Improvements of self-rated mood were also found following the Centella asiatica treatment.

https://www.ncbi.nlm.nih.gov/pubmed/18191355

May improve mood

https://www.ncbi.nlm.nih.gov/pubmed/28878245

Neuroprotective effects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973491/

Antidepressant effects in mice

https://www.ncbi.nlm.nih.gov/pubmed/15058206

Oral use of C. asiatica and in vitro studies improved memory and cognition,

http://www.acanceresearch.com/cancer-research/medicinal-property-of-gotu-kola-centella-asiatica-from-the-selection-of-traditional-applications-to-the-novel-phytotherapy.php?aid=8091

Results indicated that Centella asiatica may be useful in the treatment of GAD and may be used as a promising anxiolytic agent in near future.

https://www.ncbi.nlm.nih.gov/pubmed/20677602

https://www.ncbi.nlm.nih.gov/pubmed/11106141

 

SUMMARY:

https://www.selfhacked.com/blog/gotu-kola-2/

Yerba Mate 10:1 Extract (Ilex Paraguariensis)

Yerba Mate has been shown to be hypocholesterolemic, hepatoprotective, central nervous system stimulant, diuretic, and to benefit the cardiovascular system. It has also been suggested for obesity management. Yerba Mate protects DNA from oxidation and in vitro low-density lipoprotein lipoperoxidation and has a high antioxidant capacity.

https://www.ncbi.nlm.nih.gov/pubmed/18034743

Yerba mate can boost the immune system. Yerba mate is high in compounds called saponins. Saponins are natural emulsifiers that boost the immune system and have antioxidant and anti-inflammatory properties. Yerba mate also contains potent antioxidants known as polyphenols.

Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways

https://www.ncbi.nlm.nih.gov/pubmed/19807157

Yerba Mate Tea (Ilex paraguariensis): A Comprehensive Review on Chemistry, Health Implications, and Technological Considerations

https://onlinelibrary.wiley.com/doi/10.1111/j.1750-3841.2007.00535.x

Plant polyphenols as dietary antioxidants in human health and disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

High in Antioxidants

https://www.ncbi.nlm.nih.gov/pubmed/12816626

SUMMARY STUDY:

https://pdfs.semanticscholar.org/40f6/550c412de8d3e3c714756b153866e8994c1d.pdf

MORE ON YERBA MATE:

https://www.selfhacked.com/blog/yerba-mate-21-health-benefits/

Coenzyme Q10

Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

https://www.ncbi.nlm.nih.gov/pubmed/25126052

Coenzyme Q10 supplementation partially prevents the increase in lipid peroxidation after repeated short-term supramaximal exercise.

https://www.ncbi.nlm.nih.gov/pubmed/21681167/

CoQ10 may show performance-enhancing effects during the repeated bouts of supramaximal exercises and CoQ10 might be used as ergogenic aid.

https://www.ncbi.nlm.nih.gov/pubmed/19644406/

Oral administration of coenzyme Q10 improved subjective fatigue sensation and physical performance during fatigue-inducing workload trials and might prevent unfavorable conditions as a result of physical fatigue.

https://www.ncbi.nlm.nih.gov/pubmed/18272335/

Another study on the positive effects of CoQ10 on physical exertion

https://www.ncbi.nlm.nih.gov/pubmed/18318910/

CoQ10 supports sufferer’s of coronary artery disease

https://www.ncbi.nlm.nih.gov/pubmed/21996047

Natural Caffeine Powder

Caffeine led to increased alertness and improved performance on simple and choice reactive tasks, a cognitive vigilance task, a task requiring sustained response and a dual task involving tracking and target detection.

https://www.ncbi.nlm.nih.gov/pubmed/12404081?dopt=Abstract

Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep.

https://www.ncbi.nlm.nih.gov/pubmed/25527035

Caffeine enhanced consolidation of long-term memories in humans.

https://www.nature.com/articles/nn.3623

This experiment found that caffeine could produce a large reduction in pain resulting from eccentric exercise–induced, delayed-onset muscle injury.

https://www.sciencedirect.com/science/article/pii/S1526590006010236

Acute doses of caffeine, at levels typically found in a cup of coffee, produce stimulant-like subjective effects and enhance performance in light, nondependent caffeine users.

https://www.ncbi.nlm.nih.gov/pubmed/16541243

Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory.

https://www.ncbi.nlm.nih.gov/pubmed/18554731

The effect of caffeine ingestion on mood state and bench press performance to failure.

https://www.ncbi.nlm.nih.gov/pubmed/21157384

NA-R-ALA Stabilized R-Lipoic Acid

Supplementation with alpha-lipoic acid may positively impact patients with HIV and acquired immune deficiency syndrome by restoring blood total glutathione level and improving functional reactivity of lymphocytes to T-cell mitogens

https://www.ncbi.nlm.nih.gov/pubmed/18315507

It is concluded that alpha-lipoic acid supplementation diminishes oxidative damage

https://www.ncbi.nlm.nih.gov/pubmed/19617657

Alpha-lipoic acid, a natural thiol antioxidant, has been shown to have beneficial effects on oxidative stress parameters in various tissue

https://www.ncbi.nlm.nih.gov/pubmed/25104975

Alpha-lipoic acid supplementation could significantly decrease CRP level in patients with elevated levels of this inflammatory marker

https://www.sciencedirect.com/science/article/pii/S0939475318301248

Administration of lipoic acid to patients with the metabolic syndrome improves endothelial function and reduces proinflammatory markers, factors that are implicated in the pathogenesis of atherosclerosis

https://www.ncbi.nlm.nih.gov/pubmed/15655130

Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis

https://www.ncbi.nlm.nih.gov/pubmed/16644024

 

MORE ON ALA

https://www.selfhacked.com/blog/lipoic-acid/

L-Tyrosine

Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/

Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans

https://www.ncbi.nlm.nih.gov/pubmed/2736402

Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course

https://www.ncbi.nlm.nih.gov/pubmed/10230711

The effects of tyrosine on cognitive performance during extended wakefulness

https://www.ncbi.nlm.nih.gov/pubmed/7794222

Behavioral and cognitive effects of tyrosine intake in healthy human adults

https://www.ncbi.nlm.nih.gov/pubmed/25797188

Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review

https://www.ncbi.nlm.nih.gov/pubmed/26424423

Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance

https://www.ncbi.nlm.nih.gov/pubmed/25598314

L-Tyrosine to alleviate the effects of stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/

Taurine

Taurine and inflammatory diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894431/

Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species

https://www.ncbi.nlm.nih.gov/pubmed/20360629

Effects of taurine administration on exercise

https://www.ncbi.nlm.nih.gov/pubmed/19239155

Effects of taurine on rat behaviors in three anxiety models

https://www.ncbi.nlm.nih.gov/pubmed/16540157/

Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo

https://www.ncbi.nlm.nih.gov/pubmed/17728537

Antidepressant-like effect of chronic taurine administration and its hippocampal signal transduction in rats.

https://www.ncbi.nlm.nih.gov/pubmed/23392922

Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504064/

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994368/

Acetyl L-Carnitine

L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial

https://www.ncbi.nlm.nih.gov/pubmed/18065594

L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study

https://www.ncbi.nlm.nih.gov/pubmed/17693145

Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome

https://www.ncbi.nlm.nih.gov/pubmed/15039515

Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue

https://www.ncbi.nlm.nih.gov/pubmed/17658628

The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery

https://www.ncbi.nlm.nih.gov/pubmed/12930169

Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise

https://www.ncbi.nlm.nih.gov/pubmed/18545197

L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress

https://www.ncbi.nlm.nih.gov/pubmed/11788381

l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women

https://www.ncbi.nlm.nih.gov/pubmed/20045157

A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia

https://www.ncbi.nlm.nih.gov/pubmed/16316746

Antidepressant-like effect of artemin in mice: A mechanism for acetyl-l-carnitine activity on depression

https://www.researchgate.net/publication/51144465_Antidepressant-like_effect_of_artemin_in_mice_A_mechanism_for_acetyl-l-carnitine_activity_on_depression

Acetyl-L-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders

https://www.tandfonline.com/doi/full/10.1517/13543784.17.6.827

Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial

https://www.sciencedirect.com/science/article/pii/S0022510X03003551

Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression

https://www.ncbi.nlm.nih.gov/pubmed/21590285

Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue

https://www.ncbi.nlm.nih.gov/pubmed/17658628

 

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